报告题目：Tailoring Clay Nanoparticles for Efficient Healthcare
报告人：Zhi Ping (Gordon) XU教授
I will introduce a clay nanoparticle,i.e.layered double hydroxide (LDH) nanoparticle, and then demonstrate its high potential as the drug/gene delivery platforms. The first example is the topical delivery of double-stranded RNA (dsRNA) for efficient control of specific plant viruses, which has been published in Nature Plants.
The second example is using LDH nanoparticles to orally delivery non-steroidal anti-inflammatory drugs (NSAIDs), which is based a patent transferred to a UK company for commercialization. I will present a few examples to show efficient co-delivery of functional small interfering RNA (siRNA) and anti-cancer drug to cancer cells for the synergic inhibition.
The third example is using clay nanoparticles as vaccine adjuvants to promote higher and long-term immune responses against cancer and bacteria. We have noted that LDH is able to readily load model antigen ovalbumin (OVA) and the toll-like receptor ligand CpG together, promote higher levels of specific antibodies, and modulate the immune response from Th2 bias towards the preferred polarity Th1 for anti-cancer purpose. A recent results will be included to demonstrate the potential therapeutic multi-antigen vaccine for skin cancer immunotherapy.
In the final part, I will demonstrate the capability of inorganic nanoparticles as positron emission tomography (PET) and magnetic resonance imaging (MRI) contrast agents for cancer imaging and detection, and the combinational therapy to effectively control the tumor tissues in mice.
Prof. Zhi Ping (Gordon) Xu is the professor of Australian Institute for Bioengineering and Nanotechnology and UQ VC Senior Research Fellow at The University of Queensland, Australia. He received his PhD from National University of Singapore in 2001. His research areas focus on the control preparation of clay nanomaterials, calcium phosphate nanoparticles, quantum dots, nanoemulsion, liposome, Au/Ag nanoparticles, upconversion nanoparticles and biosensors; delivery of drugs and gene to treat cancers and other diseases; development of nanoadjuvants for enhanced immunisation for human health and animal health; imaging and diagnosis of normal and disease tissues (in particular tumour tissues); and development of nanotechnology for crop protection and weed growth control. He has published more than 240 peer-reviewed papers, including Nature Plants, Adv. Mater., J. Am. Chem. Soc., ACS Nano, Nano Lett., Biomaterials, Small, J. Control. Release, Chem. Commun., Nanoscale,etc., and the total citation is over 9300. He serves as the associate editor of RSC Adv., editorial board member for 6 journals, and reviewer of more than 20 journals, such as J. Am. Chem. Soc., Biomaterials, Small, Nature Commun., Nanoscale, Adv. Funct. Mater., Chem. Mater., J Mater. Chem.etc.